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5 The authors found that after multivariate adjustment, IL-6 was weakly associated and CRP was strongly associated with the risk of hypertension

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Therefore, an increase of UGT2B17 protein can increase ligand-independent AR signalling (mainly determined by constitutively active AR-Vs) and androgen insensitivity in castrate conditions by inducing increased testosterone excretion (164, 165) and thus progressing the disease